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It is part of the San Diego–Tijuana conurbation, the second-largest transborder agglomeration between the US and a bordering country after Detroit–Windsor, with a population of 4,922,723 people.The city is known for its mild year-round climate, natural deep-water harbor, extensive beaches, long association with the United States Navy, and recent emergence as a healthcare and biotechnology development center.San Diego has been called "the birthplace of California".Historically home to the Kumeyaay people, it was the first site visited by Europeans on what is now the West Coast of the United States.Sailing his flagship San Salvador from Navidad, New Spain, Cabrillo claimed the bay for the Spanish Empire in 1542, and named the site "San Miguel".In November 1602, Sebastián Vizcaíno was sent to map the California coast.
California became part of the United States in 1848 following the Mexican–American War and was admitted to the union as a state in 1850.
Upon landing in San Diego Bay in 1542, Juan Rodríguez Cabrillo claimed the area for Spain, forming the basis for the settlement of Alta California 200 years later.
The Presidio and Mission San Diego de Alcalá, founded in 1769, formed the first European settlement in what is now California.
Arriving on his flagship San Diego, Vizcaíno surveyed the harbor and what are now Mission Bay and Point Loma and named the area for the Catholic Saint Didacus, a Spaniard more commonly known as San Diego de Alcalá.
On November 12, 1602, the first Christian religious service of record in Alta California was conducted by Friar Antonio de la Ascensión, a member of Vizcaíno's expedition, to celebrate the feast day of San Diego.